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French National Institute of Health and Medical Research (INSERM)
Phone number: 
+33 2 35 14 66 47
+33 2 35 14 69 46

Research topics

Dr Jérôme Leprince is a peptide chemist who has been working for 20 years on the structure-activity relationships of neuropeptides with significant successes in the design of potent and stable agonists and antagonists of G protein-coupled receptors. His fields of investigation encompass essentially the areas of the central control of energy metabolism and neuroprotection processes. He has also a recognized expertise in the characterization of antimicrobial peptides from frog skin secretions and their transformation into therapeutically valuable anti-infective agents.


C. Zatylny-Gaudin, B. Bernay, B. Zanuttini, J. Leprince, H. Vaudry, J. Henry, Characterization of a novel LFRFamide neuropeptide in the cephalopod Sepia officinalis., Peptides. 31 (2010) 207–14.
J. Pasquier, A.-G. Lafont, J. Leprince, H. Vaudry, K. Rousseau, S. Dufour, First evidence for a direct inhibitory effect of kisspeptins on LH expression in the eel, Anguilla anguilla. Gen. Comp. Endocrinol. 173 (2011) 216–25.
A. Servili, Y. Le Page, J. Leprince, A. Caraty, S. Escobar, I.S. Parhar, J.Y. Seong, H. Vaudry, O. Kah, Organization of two independent kisspeptin systems derived from evolutioanry-ancient kiss genes in the brain of zebrafish. Endocrinology 152 (2011) 1527–40.
J. Enault, C. Zatylny-Gaudin, B. Bernay, B. Lefranc, J. Leprince, M. Baudy-Floc’h, J. Henry, A complex set of sex pheromones identified in the cuttlefish Sepia officinalis. PlosOne 7 (2012) e46531.
F.B. Quan, C. Dubessy, S. Galant, N.B. Kenigfest, L. Djenoune, J. Leprince, C. Wyart, I. Lihrmann, H. Tostivint, Comparative distribution and in vivo activities of the urotensin II-related peptides URP1 and URP2 in zebrafish: evidence for their colocalization in spinal cerebrospinal fluid-contacting neurons. PlosOne 10 (2015) e0119290