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Museum National d'Histoire Naturelle (MNHN) - Sorbonne Universités
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+33 1 40 79 53 48

Research topics

Eco-Evo-Devo approach of nervous system in the cephalopod Sepia officinalis
Our research topic deal with organogenesis of the central and peripheral nervous system and the sensorial structures associated, in an adaptive context. We work, with this mollusc showing very derived characters, on the genes and molecular pathways involved in the neurogenesis: in particular transcription factors (Pax and NK families…) and morphogens (shh) but also receptors and their ligand involved in the perception and/or relation with the environment. We test in Sepia some environmental factors such as the light, in order to test selective constraints during the development.
Results obtained on the cuttlefish as a Lophotrochozoan model allow to explore in a comparative approach the evolution, the diversity and the role of the genes and molecular network involved in the setting up of an organism, in the aquatic coastal environment.
Method used: in situ hybridization, Immunostaining, Histology


S. Aroua, A. Andouche, M. Martin, S. Baratte, L. Bonnaud, FaRP cell distribution in the developing CNS suggests involvement of FaRP in all parts of the chromatophore control pathway in Sepia officinalis (Cephalopoda), Zoology.  114 (2011) 113-122.
A. Buresi, S. Baratte, C. Da Silva, L. Bonnaud, orthodenticle/otx ortholog expression in the anterior brain and eyes of Sepia officinalis (Mollusca, Cephalopoda), Gene Expr. Patterns, 12 (2012) 109-116.
M. Nomaksteinsky, S. Kassabov, Z. Chettouh, H.C. Stoeklé, L. Bonnaud, G. Fortin, E.R. Kandel, J.F. Brunet, Deep homology of somatic and visceral neurons among bilaterians, BMC Biol. 11 (2013) 53.
F. Bouteau, Y. Bassaglia, E. Monetti, D. Tran, S. Navet , S. Mancuso, H. El-Maarouf-Bouteau, L. Bonnaud-Ponticelli, Could FaRP-like peptides participate in regulation of hyperosmotic stress responses in plants?, Front. Endocrinol. 5 (2014)1-9.
S. Navet, S.Baratte, Y. Bassaglia, A. Andouche, A. Buresi, L. Bonnaud, Neurogenesis in cephalopods: Eco-Evo-Devo approach in the cuttlefish Sepia officinalis (Mollusca-Cephalopoda), J. Mar. Sci. Technol. 22 (2014) 15-24